Please use this identifier to cite or link to this item: http://hdl.handle.net/10125/32036

Chemical Sterilization

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Item Summary

Title: Chemical Sterilization
Authors: Nishida, Gary
Issue Date: 15 Jan 2014
Publisher: University of Hawaii at Manoa
Abstract: The contraceptive and behavioral effects of intrauterine injections of various sclerosing agents were examined in the hamster. Silver nitrate, sodium tetradecyl sulfate, ethanol formalin, and quinacrine were found to be effective in causing intrauterine occlusions. Multiple transvaginal injections of quinacrine were found to be effective in preventing pregnancy as long as 125 days after the last administration of the drug. Single injections of quinacrine, while initially effective in preventing pregnancy, did not result in a permanent sterilizing effect. Intrauterine quinacrine injections altered neither estrous cyclicity nor copulatory behavior. Quinacrine, in addition to its sterilizing properties, was found to have abortifacient properties if injected after implantation of the fetuses. With poor technique, a side effect to be considered was intestinal adhesion resulting from peritoneal exposure to the sclerosing agents.
Pages/Duration: 28 pages
URI/DOI: http://hdl.handle.net/10125/32036
Rights: All UHM Honors Projects are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission from the copyright owner.
Appears in Collections:Honors Projects for Biology



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