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Detection of Mutagens in the Areca Nut with Two Microbial Assays

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Title: Detection of Mutagens in the Areca Nut with Two Microbial Assays
Authors: Yen, Catherine
Issue Date: 15 Jan 2014
Publisher: University of Hawaii at Manoa
Abstract: The areca nut (Areca catechu Linn.) is commonlychewed in India and other eastern countries, and this practice has been associated with an increased incidence of oral cancer. Most known carcinogens are also mutagens, therefore it is probable that areca nuts contain a mutagen. A host-mediated and an in vitro microbial assay were used to screen the areca nut for mutagens. Neither the whole nut nor extracts of it showed any evidence of mutagenic activity. The urine of mice fed the areca likewise gave no indications of mutagenicity. It is possible that the nut does not contain a mutagen, or that a mutagen in the nut is not concentrated enough to detect with the assays used.
Pages/Duration: 24 pages
URI/DOI: http://hdl.handle.net/10125/31994
Rights: All UHM Honors Projects are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission from the copyright owner.
Appears in Collections:Honors Projects for Biology



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