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Studies on the Cardiotoxic Interaction between Sympathomimetic Amies and Digitalis

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Title: Studies on the Cardiotoxic Interaction between Sympathomimetic Amies and Digitalis
Authors: Yano, Stephen
Issue Date: 15 Jan 2014
Publisher: University of Hawaii at Manoa
Abstract: This study was undertaken to investigate the mechanism of the cardiotoxic interaction between sympathomimetics and digitalis which results in the production of cardiac arrhythmias. Previous work had established that sympathomimetics can stimulate both the influx as well as the efflux of potassium from cells. Observation that digitalis toxicity has been noted to produce an efflux of K+ from the cell be- cause the drug inhibits the sodium pump (Na+-K+ ATPase), suggested that the forementioned cardiotoxic interaction may be related to a combina- tion of the kalemotropic effects of sympathomimetics and the inhibition of Na+-K+ ATPase by digitalis with a resultant facilitated loss of myocardial potassium.
Pages/Duration: v, 56 pages
Rights: All UHM Honors Projects are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission from the copyright owner.
Appears in Collections:Honors Projects for Biology

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