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Association of leptin, 25-hydroxyvitamin D, and parathyroid hormone in women.

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Title: Association of leptin, 25-hydroxyvitamin D, and parathyroid hormone in women.
Authors: Maetani, Micah
Maskarinec, Gertraud
Franke, Adrian A.
Cooney, Robert V.
Issue Date: 2009
Citation: Maetani, M., G. Maskarinec, A. A. Franke, and R. V. Cooney. "Association of leptin, 25-hydroxyvitamin D, and parathyroid hormone in women." Nutrition and cancer 61, 2 (2009): 225-31. doi: 10.1080/01635580802455149.
Abstract: Vitamin D deficiency and adipocytokines have been implicated in the etiology of aging-related diseases such as cancer, osteoporosis, and diseases of the cardiovascular system. The association between elevated parathyroid hormone (PTH) and low 25-hydroxyvitamin D (25-OH-VitD) in plasma is used to define vitamin D deficiency, yet their associated mechanistic pathways are unclear. Utilizing plasma samples from women in a previous intervention study, we measured plasma 25-OH-VitD, leptin, adiponectin, PTH, and lipid levels. We observed strong positive associations for leptin with PTH, gamma -tocopherol, and body mass index (BMI) and inverse associations with 25-OH-VitD and adiponectin. Although commonly accepted that vitamin D deficiency causes hyperparathyroidism, we observed this association primarily in individuals with elevated leptin levels, suggesting that leptin may be an important modifier of this effect consistent with 25-OH-VitD-mediated inhibition of leptin. Leptin was highly correlated with the BMI/25-OH-VitD ratio (r = 0.80; P < 0.0001), consistent with a model in which BMI (adiposity) and 25-OH-VitD are the primary determinants of circulating leptin and PTH levels. This model may explain the failure of some studies to observe elevated PTH in vitamin D deficient adolescents and provides important insight into epidemiological studies exploring the associations of these individual biomarkers with chronic disease risk and mortality.
DOI: 10.1080/01635580802455149
Appears in Collections:Cooney, Robert V.
Cooney, Robert V.

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