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Traditional Thai Medicines Inhibit Helicobacter pylori in vitro and in vivo: Support for Ethnomedical Use

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Title: Traditional Thai Medicines Inhibit Helicobacter pylori in vitro and in vivo: Support for Ethnomedical Use
Authors: Mahady, Gail B.
Bhamarapravati, Sutatip
Adeniyi, Bolanle A.
Doyle, Brian
Locklear, Tracie
show 2 moreSlover, Christine
Pendland, Susan L.

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Keywords: ethnobotany
traditional medicine
Thailand
Heliobacter pylori
in vivo studies
show 15 morein vitro studies
digestive system diseases
gastritis
peptic ulcers
plant extracts
medicinal plants
Curcuma longa
Boesenbergia rotunda
etiology
gastric cancer
Gram-negative bacteria
carcinogens
animal disease models
Meriones unguiculatus
turmeric

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Issue Date: 2006
Publisher: University of Hawaii at Manoa
Citation: Mahady GB, Bhamarapravati S, Adeniyi BA, Doyle B, Locklear T, Slover C, Pendland SL. 2006. Traditional Thai medicines inhibit Helicobacter pylori in vitro and in vivo: support for ethnomedical use. Ethnobotany Research & Applications 4:159-166.
Abstract: In Thailand, traditional plant-based medicines have always been used to treat gastrointestinal ailments, including gastritis, peptic ulcer disease (PUD) and diarrhea. Since Helicobacter pylori (HP) is an etiological agent of PUD, we have used an ethnomedical approach for screening plant extracts as potential treatments for HP infections, including over 20 species from Thailand. International Memoranda of Agreement were established between UIC and Mahidol University in Thailand. Medicinal plants were collected, identified and extracted. Susceptibility testing was performed with 15 HP strains using the agar dilution procedure guidelines of the Clinical and Laboratory Standards Institute. In vivo studies included evaluating bacterial load, as well as acute and chronic inflammation in HP-infected Mongolian gerbils. Extracts of Curcuma longa L. and Boesenbergia rotunda (L.) Mansf. significantly reduced HP-induced gastric lesions, as assessed both macroscopically and microscopically in Mongolian gerbils. The treatments reduced acute and/or chronic inflammation in a prevention model of HP-induced gastritis.
URI/DOI: http://hdl.handle.net/10125/249
ISSN: 1547-3465
Appears in Collections:2006 - Volume 4 : Ethnobotany Research and Applications



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