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Effects of vitamin D3 and calcium supplementation on serum levels of tocopherols, retinol, and specific vitamin D metabolites
|Title:||Effects of vitamin D3 and calcium supplementation on serum levels of tocopherols, retinol, and specific vitamin D metabolites|
Franke, Adrian A.
Custer, Laurie J.
show 1 moreCooney, Robert V.
|Keywords:||Vitamin D, gamma-tocopherol, Vitamin E, leptin|
|Issue Date:||Jan 2012|
|Citation:||Nutrition and Cancer, 64:1, 57-64|
|Abstract:||-Tocopherol (T) protects against DNA-damaging effects of nitrogen oxides, yet its physiologic regulation in vivo is unknown. Observational studies indicate inverse associations of 25[OH]-vitamin D with T and leptin. To determine whether vitamin D3 supplementation alters levels of lipid-soluble micronutrients, serum samples (N=85 subjects) from a randomized, double-blind, placebo-controlled clinical trial of vitamin D3 (800 IU) and calcium (2 g) alone and in combination were analyzed for lipid micronutrients and specific vitamin D metabolites at baseline and after 6-months of supplementation. Serum 25[OH]-vitaminD3 levels increased 55% (P < 0.0001) and 48% (P = 0.0005), whereas 25[OH]-vitaminD2 levels decreased by 48% (P = 0.26) and 21% (P = 0.36) in the vitamin D3 and vitamin D3 plus calcium groups, respectively. At baseline, T levels were inversely associated with 25[OH]D (r = -0.31, P = 0.004). With vitamin D3 plus calcium treatment, serum α-tocopherol decreased 14% (P = 0.04), while similar changes in T (19% decrease, P = 0.14) were observed. No significant effects were observed for D3 supplementation on leptin or retinol levels. These results are consistent with the hypothesis that vitamin D3 +/- calcium affects serum tocopherol and 25[OH]D2 levels, however, studies utilizing larger populations are warranted.|
|Sponsor:||This research was supported in part by the National Institutes of Health grants R01CA104637 and R03CA132149, and Georgia Cancer Coalition Distinguished Scholar award (to RMB). WC was supported by a postdoctoral fellowship on grant R25 CA90956.|
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|Appears in Collections:||Cooney, Robert V.|
Cooney, Robert V.
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