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Title: Effects of vitamin D3 and calcium supplementation on serum levels of tocopherols, retinol, and specific vitamin D metabolites 
Author: Chai, Weiwen; Bostick, Roberd; Ahearn, Thomas; Franke, Adrian A.; Custer, Laurie J.; Cooney, Robert V.
Date: 2012-01
Publisher: Routledge
Citation: Nutrition and Cancer, 64:1, 57-64
Abstract: -Tocopherol (T) protects against DNA-damaging effects of nitrogen oxides, yet its physiologic regulation in vivo is unknown. Observational studies indicate inverse associations of 25[OH]-vitamin D with T and leptin. To determine whether vitamin D3 supplementation alters levels of lipid-soluble micronutrients, serum samples (N=85 subjects) from a randomized, double-blind, placebo-controlled clinical trial of vitamin D3 (800 IU) and calcium (2 g) alone and in combination were analyzed for lipid micronutrients and specific vitamin D metabolites at baseline and after 6-months of supplementation. Serum 25[OH]-vitaminD3 levels increased 55% (P < 0.0001) and 48% (P = 0.0005), whereas 25[OH]-vitaminD2 levels decreased by 48% (P = 0.26) and 21% (P = 0.36) in the vitamin D3 and vitamin D3 plus calcium groups, respectively. At baseline, T levels were inversely associated with 25[OH]D (r = -0.31, P = 0.004). With vitamin D3 plus calcium treatment, serum α-tocopherol decreased 14% (P = 0.04), while similar changes in T (19% decrease, P = 0.14) were observed. No significant effects were observed for D3 supplementation on leptin or retinol levels. These results are consistent with the hypothesis that vitamin D3 +/- calcium affects serum tocopherol and 25[OH]D2 levels, however, studies utilizing larger populations are warranted.
Sponsorship: This research was supported in part by the National Institutes of Health grants R01CA104637 and R03CA132149, and Georgia Cancer Coalition Distinguished Scholar award (to RMB). WC was supported by a postdoctoral fellowship on grant R25 CA90956.
Pages/Duration: 22
URI: http://dx.doi.org/10.1080/01635581.2012.630552
http://hdl.handle.net/10125/24282
Rights: Full terms and conditions of use: http://www.tandfonline.com/page/terms-and-conditions This article may be used for research, teaching, and private study purposes. Any substantial or systematic reproduction, redistribution, reselling, loan, sub-licensing, systematic supply, or distribution in any form to anyone is expressly forbidden. The publisher does not give any warranty express or implied or make any representation that the contents will be complete or accurate or up to date. The accuracy of any instructions, formulae, and drug doses should be independently verified with primary sources. The publisher shall not be liable for any loss, actions, claims, proceedings, demand, or costs or damages whatsoever or howsoever caused arising directly or indirectly in connection with or arising out of the use of this material.
Keywords: Vitamin D, gamma-tocopherol, Vitamin E, leptin

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