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Title: Acquisition and consolidation of contextual fear conditioning : role of CRF receptor in shock or predator odor induced fear 
Author: Nakashima, Brandy R
Date: 2007
Abstract: Learning is critical to survival, and studying the mechanisms underlying learning can help us understand learning and disorders associated with disturbed learning. Corticotropin-releasing factor (CRF), a 4 I-amino acid peptide, regulates the hypothalamic-pituitary-adrenal (HP A) axis and the behavioral response to fearful stimuli. Manipulation of the CRF system can alter the behavioral and physiological responses to a fearful stimulus, potentially disrupting the ability to learn about that stimulus. The current study examines the effects of a specific CRF receptor antagonist, DMP696, on fear conditioning with two different fear stimuli. Various doses ofDMP696 including vehicle were administered orally to rats 60 minutes prior to fear conditioning. The animals were exposed to foot shock or cat odor during an acquisition test. Testing for conditioned fear was conducted 48 hours after drug administration. DMP696 or vehicle was not administered on the conditioned fear test day. DMP696 dose dependently decreased footshock-induced conditioned freezing but did not alter the acquisition of fear. These results suggest CRF 1 receptors playa role in the consolidation of footshock-induced conditioned fear. In contrast, DMP696 did not affect unconditioned fear to cat odor or conditioned fear to a context where cat odor had been present, indicating CRF J receptors do not playa significant role in cat odor-induced fear conditioning. These contrasting results provide further support to theories implicating multiple pathways for fear conditioning. Several researchers have suggested that the importance of fear learning has led to the development of multiple pathways to support fear-related learning. Previous research has indicated the presence of separate pathways supporting shock-induced and predator odor-induced fear conditioning.
Description: Thesis (M.A.)--University of Hawaii at Manoa, 2007. Includes bibliographical references (leaves 19-22). v, 22 leaves, bound ill. 29 cm
URI: http://hdl.handle.net/10125/20853
Rights: All UHM dissertations and theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission from the copyright owner.
Keywords: Corticotropin releasing hormone, Fear in animals

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