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Title: Research on the diversity and the biomedical potential of marine fungi in Hawaii 
Author: He, Mingxiao
Date: 2007
Abstract: This study was designed to survey the diversity of marine fungi in Hawaiian waters using molecular biological methods and to do preliminary screening for biological isolates with pharmaceutical potential based on biological activities. 106 marine fungal isolates were isolated from nine algae species from eight different locations around the coast of the Hawaii Island in Hawaii. These fungal isolates were classified based on the ribosomal internal transcribed spacer regions, and were found to represent 10 orders including 57 species of Ascomycota, and 2 orders including 3 species of Basidiomycota. Two isolates, Haw 3BII and Haw 7A3, representing long phylogenetic distances from known sequences in Genbank, are potential new species. Anti-bacterial assays were performed with the crude extracts obtained from the cultures of 70 algae associate fungi in Hawaii. In total, eight extracts shown inhibitory activity to Bacillus subtilis and four to Staphylococcus aureus, respectively. None inhibited activity to the gram negative bacteria Pseudomonas aeruginosa and E.coli K12. Anti-tumoral assays using murine cell lines BCN (non-tumorgenic) and L88 (tumorgenic) were performed with the crude extracts of the cultures of 70 algae associated fungi and 58 sponge-associated fungi. In total, four extracts, one from algae- associated fungi and three from sponge-associated fungi, showed strong inhibition of L88 and slight or no inhibition of BCN. Those isolates will be further studied for their potential in drug discovery.
Description: Thesis (M.S.)--University of Hawaii at Manoa, 2007. Includes bibliographical references (leaves 50-54). x, 54 leaves, bound ill. 29 cm
Rights: All UHM dissertations and theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission from the copyright owner.
Keywords: Marine fungi -- Hawaii

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Restricted for viewing only M.S.Q111.H3_4207 AUG 2007_r.pdf 2.350Mb PDF View/Open
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