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Deconvolution of light scattering and diffuse reflectance signatures for delineation of mucosal cancer cells using wavelet analysis

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Item Summary

Title: Deconvolution of light scattering and diffuse reflectance signatures for delineation of mucosal cancer cells using wavelet analysis
Authors: Hernandez, Luis Manuel Ortiz
Keywords: Cancer -- Diagnosis -- Equipment and supplies
Mucous membrane -- Cancer
Issue Date: 2005
Abstract: This thesis presents a technique to measure cells using a Fabry-Perot optical model along with wavelet decomposition applied to the reflected or transmitted optical spectrum. Cell size measurement is used as an indicator in early diagnosis of cancer. This research is based on developing a non-invasive, optical system to detect dysplasia in mucosal tissues; this is achieved by analysis of the reflectance or transmittance spectrum to determine the mutated cells' sizes. The collected spectrum contains information about the cell's internal structure. To decode this information, an optical cell model was formulated to create a custom mother wavelet to be used to deconvolve the absorption and light scattering components of the collected spectra. Finally, the previous results are fitted to different models for prediction, of cell sizes and the results with the least error are presented as a Gaussian distribution.
Description: Thesis (M.S.)--University of Hawaii at Manoa, 2005.
Includes bibliographical references (leaves 71-72).
xii, 89 leaves, bound ill. 29 cm
URI/DOI: http://hdl.handle.net/10125/20548
Rights: All UHM dissertations and theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission from the copyright owner.
Appears in Collections:M.S. - Electrical Engineering



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