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Total synthesis of (+)-madindoline A and (+)- madindoline B
|M.S.Q111.H3_4148 DEC 2006_r.pdf||Version for non-UH users. Copying/Printing is not permitted||1.96 MB||Adobe PDF||View/Open|
|M.S.Q111.H3_4148 DEC 2006_uh.pdf||Version for UH users||1.95 MB||Adobe PDF||View/Open|
|Title:||Total synthesis of (+)-madindoline A and (+)- madindoline B|
Total synthesis of plus-madindoline A and plus- madindoline B
Cells -- Growth -- Regulation
|Abstract:||A formal total synthesis of (+ )-madindoline A and (+ )-madindoline B, highly selective inhibitors of interleukin-6, has been accomplished in 11 steps with an overall yield of 8.3% from hexanoic acid. The allene ether version of the Nazarov cyc1ization was used to form the cyclopentenone core of the madindolines. The quaternary carbon center was generated from a ZnBr2-catalyzed condensation reaction between silyl enol ether 2.24 and thioether 2.50.|
|Description:||Thesis (M.S.)--University of Hawaii at Manoa, 2006.|
Includes bibliographical references (leaves 83-86).
x, 86 leaves, bound ill. 29 cm
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|Appears in Collections:||M.S. - Chemistry|
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