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Title: Small vessel vascular disease in HIV infection 
Author: McMurtray, Aaron
Date: 2007
Abstract: Background: This study is designed to determine the relationship between age and occurrence of cerebral manifestations of small vessel ischemic vascular disease in HIV seropositive individuals. Methods: Periventricular leukoaraiosis severity and white matter lesion volume were determined by magnetic resonance imaging (MRI) of the brain on 57 HIV seropositive individuals. Results: Cerebral small vessel ischemic vascular disease manifestations correlated with age and systolic blood pressure, but not with HIV infection-related parameters. Conclusion: These findings suggest that, in the era of highly active antiretroviral therapy, leukoaraiosis severity and white matter lesion volume may be more indicative of small vessel ischemic vascular disease than HIV -related CNS pathology; and support the need for aggressive treatment of vascular risk factors in HIV seropositive individuals.
Description: Thesis (M.S.)--University of Hawaii at Manoa, 2007. Includes bibliographical references (leaves 13-17). vii, 17 leaves, bound ill. 29 cm
URI: http://hdl.handle.net/10125/20430
Rights: All UHM dissertations and theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission from the copyright owner.
Keywords: Cerebral ischemia -- Age factors, HIV infections -- Complications

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