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dc.contributor.advisor McFall-Ngai, Margaret en_US Kimbell, Jennifer Loraine en_US 2008-04-17T18:45:52Z 2008-04-17T18:45:52Z 2003-12 en_US
dc.identifier.citation Kimbell, Jennifer Loraine (2003) Symbiont-induced changes in host gene expression: The squid-Vibrio symbiosis. Ph.D. dissertation, University of Hawai'i, United States -- Hawaii. en_US
dc.description.abstract All animals exist in lifelong relations with a complement of bacteria. Because of the ubiquity of these symbioses as well as the derived biomedical applications, the study of both beneficial and pathogenic host-microbe associations has long been established. The monospecific light organ association between the Hawaiian sepiolid squid Euprymnascolopes and the marine luminous bacterium Vibrio fischeri has been used as a experimental model for the study of the most common type of animal-bacterial interaction, i.e., the association of coevolved Gram-negative bacteria with the extracellular apical surfaces of polarized epithelia. A fundamental step for understanding the mechanisms of host-symbiont associations lies in defining the genetic components involved; specifically defining changes in host gene expression. The studies presented in this dissertation identify and characterize V. fischeri-induced changes in host gene expression at both the transcript and protein level. en_US
dc.language.iso en-US en_US
dc.publisher University of Hawaii at Manoa en_US
dc.relation Theses for the degree of Doctor of Philosophy (University of Hawaii at Manoa). Biomedical Sciences (Cell & Molecular Biology); no. 4398 en_US
dc.rights All UHM dissertations and theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission from the copyright owner. en_US
dc.rights.uri en_US
dc.subject Host gene expression en_US
dc.subject Symbiosis en_US
dc.subject Vibrio fischeri en_US
dc.subject Euprymna scolopes en_US
dc.subject Light organs en_US
dc.subject Cellular biology en_US
dc.subject Molecular biology en_US
dc.title Symbiont-induced changes in host gene expression: The squid-Vibrio symbiosis en_US
dc.type Thesis en_US
dc.type.dcmi Text en_US
dc.contributor.department Biomedical Sciences (Cellular & Molecular Biology) en_US 2003-12 en_US
local.identifier.callnumber AC1 .H3 no. 4398 en_US
local.thesis.degreelevel PhD en_US

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