Symbiont-induced changes in host gene expression: The squid-Vibrio symbiosis

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2003-12
Authors
Kimbell, Jennifer Loraine
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McFall-Ngai, Margaret
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Biomedical Sciences (Cellular & Molecular Biology)
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University of Hawaii at Manoa
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Abstract
All animals exist in lifelong relations with a complement of bacteria. Because of the ubiquity of these symbioses as well as the derived biomedical applications, the study of both beneficial and pathogenic host-microbe associations has long been established. The monospecific light organ association between the Hawaiian sepiolid squid Euprymnascolopes and the marine luminous bacterium Vibrio fischeri has been used as a experimental model for the study of the most common type of animal-bacterial interaction, i.e., the association of coevolved Gram-negative bacteria with the extracellular apical surfaces of polarized epithelia. A fundamental step for understanding the mechanisms of host-symbiont associations lies in defining the genetic components involved; specifically defining changes in host gene expression. The studies presented in this dissertation identify and characterize V. fischeri-induced changes in host gene expression at both the transcript and protein level.
Description
Keywords
Host gene expression, Symbiosis, Vibrio fischeri, Euprymna scolopes, Light organs, Cellular biology, Molecular biology
Citation
Kimbell, Jennifer Loraine (2003) Symbiont-induced changes in host gene expression: The squid-Vibrio symbiosis. Ph.D. dissertation, University of Hawai'i, United States -- Hawaii.
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Theses for the degree of Doctor of Philosophy (University of Hawaii at Manoa). Biomedical Sciences (Cell & Molecular Biology); no. 4398
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