Please use this identifier to cite or link to this item: http://hdl.handle.net/10125/101694

Sex differences in osmotic stimulation of vasopressin release in rats chronically exposed to alcohol

File Description SizeFormat 
Andaya_January May_r.pdfVersion for non-UH users. Copying/Printing is not permitted1.31 MBAdobe PDFView/Open
Andaya_January May_uh.pdfVersion for UH users1.36 MBAdobe PDFView/Open

Item Summary

Title: Sex differences in osmotic stimulation of vasopressin release in rats chronically exposed to alcohol
Authors: Andaya, January May
Issue Date: May 2011
Publisher: [Honolulu] : [University of Hawaii at Manoa], [May 2011]
Abstract: Whether the purported differences in alcohol effects in males and females may be due to alcohol influence on estradiol and progesterone mediation of vasopressin (VP) release was studied in Sprague-Dawley male and female rats exposed to control, moderate alcohol (1.2% ethanol) or high alcohol (6.4-6.7% ethanol) liquid diet for 4-6 weeks. VP response to an osmotic stimulus (5% NaCl i.v. infusion) and pituitary VP stores in relationship to circulating VP were examined.
In males, alcohol did not appear to affect VP osmotic stimulation. In females, however, alcohol affected VP osmotic stimulation sensitivity depending on estrous cycle phase, and appeared to alter circulating estradiol and progesterone relationships with VP stores and release. Results thus indicate that females may be more susceptible to alcoholinduced changes in VP regulation of water balance.
Description: M.S. University of Hawaii at Manoa 2011.
Includes bibliographical references.
URI/DOI: http://hdl.handle.net/10125/101694
Appears in Collections:M.S. - Biomedical Sciences (Physiology)



Items in ScholarSpace are protected by copyright, with all rights reserved, unless otherwise indicated.