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Development of an analytical method for β-methylamino-l-alanine, a cyanobacterial metabolite and potential environmental toxin and selective extraction protocol and structure of formamides of β-methylamino-l-alanine (bmaa) from cycas thouarsii

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Item Summary

Title: Development of an analytical method for β-methylamino-l-alanine, a cyanobacterial metabolite and potential environmental toxin and selective extraction protocol and structure of formamides of β-methylamino-l-alanine (bmaa) from cycas thouarsii
Authors: Miyasaka, Yoshiaki
Keywords: qualitative/quantitative analysis
SPE protocol
chemical synthesis
Issue Date: May 2014
Publisher: [Honolulu] : [University of Hawaii at Manoa], [May 2014]
Abstract: Part I: The development of a qualitative/quantitative analysis of β-Methylamino-L-alanine (BMAA), including a sample preparation protocol and SPE protocol is described. A common interfering metabolite was isolated as the FMOC-derivative. Its structure was determined by spectroscopic methods and confirmed by chemical synthesis.
Part II: The qualitative analysis of the BMAA content in samples from cycad leaf and oyster are described. Three different extraction protocols have been developed to categorize the form of BMAA present in either cycad leaf or oyster muscle. The low molecular mass conjugate of β-Methylamino-L-alanine (BMAA) in Cycas thouarsii has been identified as a mixture of regioisomeric formamides. The structures were elucidated on the basis of spectroscopic data and confirmed by chemical synthesis.
Description: M.S. University of Hawaii at Manoa 2014.
Includes bibliographical references.
URI/DOI: http://hdl.handle.net/10125/100453
Rights: All UHM dissertations and theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission from the copyright owner.
Appears in Collections:M.S. - Chemistry



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