http://hdl.handle.net/10125/1937 Sat, 18 May 2013 23:33:57 GMT 2013-05-18T23:33:57Z http://hdl.handle.net/10125/20444 Thesis (M.S.)--University of Hawaii at Manoa, 2008.; Includes bibliographical references (leaves 72-106).; xiv, 106 leaves, bound 29 cm Tue, 01 Jan 2008 00:00:00 GMT http://hdl.handle.net/10125/20444 2008-01-01T00:00:00Z Lo, Yeung Y http://hdl.handle.net/10125/20443 Thesis (M.S.)--University of Hawaii at Manoa, 2007.; Includes bibliographical references (leaves 57-63).; xii, 63 leaves, bound col. ill. 29 cm Mon, 01 Jan 2007 00:00:00 GMT http://hdl.handle.net/10125/20443 2007-01-01T00:00:00Z Munsaka, Sody http://hdl.handle.net/10125/20442 Thesis (M.S.)--University of Hawaii at Manoa, 2006.; Includes bibliographical references (leaves 62-69).; viii, 69 leaves, bound ill. 29 cm Sun, 01 Jan 2006 00:00:00 GMT http://hdl.handle.net/10125/20442 2006-01-01T00:00:00Z Co, Juliene Kimberly G http://hdl.handle.net/10125/20441 Thesis (M.S.)--University of Hawaii at Manoa, 2006.; Includes bibliographical references (leaves 88-92).; xiv, 92 leaves, bound ill. (some col.) 29 cm Sun, 01 Jan 2006 00:00:00 GMT http://hdl.handle.net/10125/20441 2006-01-01T00:00:00Z Garcia, Alan F http://hdl.handle.net/10125/20440 Thesis (M.S.)--University of Hawaii at Manoa, 2008.; Includes bibliographical references (leaves 50-53).; ix, 53 leaves, bound 29 cm Tue, 01 Jan 2008 00:00:00 GMT http://hdl.handle.net/10125/20440 2008-01-01T00:00:00Z Mueller, Brandi http://hdl.handle.net/10125/11502 Thesis (Ph. D.)--University of Hawaii at Manoa, 2004.; Includes bibliographical references (leaves 95-103).; Also available by subscription via World Wide Web; xii, 103 leaves, bound ill. (some col.) 29 cm Thu, 01 Jan 2004 00:00:00 GMT http://hdl.handle.net/10125/11502 2004-01-01T00:00:00Z Sasser, Todd http://hdl.handle.net/10125/10400 Sun, 01 Aug 2004 00:00:00 GMT http://hdl.handle.net/10125/10400 2004-08-01T00:00:00Z Chapagain, Moti Lal http://hdl.handle.net/10125/9443 Thesis (Ph. D.)--University of Hawaii at Manoa, 1995.; Includes bibliographical references (leaves 108-129).; Microfiche.; xi, 129 leaves, bound ill., maps, photos. 29 cm Sun, 01 Jan 1995 00:00:00 GMT http://hdl.handle.net/10125/9443 1995-01-01T00:00:00Z Mutambu, Susan L http://hdl.handle.net/10125/9442 Thesis (Ph. D.)--University of Hawaii at Manoa, 1993.; Microfiche.; xiv, 235 leaves, bound 29 cm Fri, 01 Jan 1993 00:00:00 GMT http://hdl.handle.net/10125/9442 1993-01-01T00:00:00Z Zhao, Zixian http://hdl.handle.net/10125/9441 Thesis (Ph. D.)--University of Hawaii at Manoa, 1992.; Includes bibliographical references (leaves 126-137); Microfiche.; x, 137 leaves, bound ill. (some col.) 29 cm Wed, 01 Jan 1992 00:00:00 GMT http://hdl.handle.net/10125/9441 1992-01-01T00:00:00Z Locher, Christopher P http://hdl.handle.net/10125/9440 Thesis (Ph. D.)--University of Hawaii at Manoa, 1990.; Includes bibliographical references (leaves 134-152); Microfiche.; xvi, 152 leaves, bound ill. 29 cm Mon, 01 Jan 1990 00:00:00 GMT http://hdl.handle.net/10125/9440 1990-01-01T00:00:00Z Terrientes S., Zilka I http://hdl.handle.net/10125/9439 Thesis (Ph. D.)--University of Hawaii at Manoa, 1990.; Includes bibliographical references (leaves 92-108); Microfiche.; ix, 108 leaves, bound ill. 29 cm Mon, 01 Jan 1990 00:00:00 GMT http://hdl.handle.net/10125/9439 1990-01-01T00:00:00Z Langford, Michael Joseph http://hdl.handle.net/10125/9438 Typescript.; Thesis (Ph. D.)--University of Hawaii at Manoa, 1985.; Bibliography: leaves 119-128.; Photocopy.; Microfilm.; ix, 128 leaves, bound ill. 29 cm Tue, 01 Jan 1985 00:00:00 GMT http://hdl.handle.net/10125/9438 1985-01-01T00:00:00Z Chu, May Chin-May http://hdl.handle.net/10125/9437 Typescript.; Thesis (Ph. D.)--University of Hawaii at Manoa, 1979.; Bibliography: leaves 147-156.; Microfiche.; x, 156 leaves ill. (some col.) 29 cm Mon, 01 Jan 1979 00:00:00 GMT http://hdl.handle.net/10125/9437 1979-01-01T00:00:00Z Keswick, Bruce H http://hdl.handle.net/10125/6851 M/emm typing was performed for clinical isolates of GAS from Hawaiʻi. Of the 54 M/emm types found, 41% belonged to recently validated or newer sequence types. M/emm 4, 12, 28 and 1 were most frequently found throat associated. M/emm 85 and 63 were found frequently skin associated and emm 66 and 81 were more frequently associated with invasive disease. When tested for adherence, isolates from the skin, throat or invasive disease did not adhere differently to Hep-2 or HaCaT cell lines. When comparing isolates from invasive and noninvasive disease, no statistically significant difference was found. The degree of adherence among the isolates did not correlate with presence or absence of fibronectin binding protein genes or opacity factor production. Isolates 322 and 328 were recovered from the same nine-year old male subject. Isolate 322 was obtained when he had pharyngitis whereas isolate 328 was cultured from his blood four days later. Both isolates shared a number of identical characteristics. Both isolates sequenced as emm 81 and the sequence of the hypervariable region showed 100% identity. They shared the same T pattern, possessed the same pulsed-field gel electrophoresis, biochemical and fibronectin binding protein genetic profiles. Both were opacity factor positive. Despite these similarities, marked phenotypic differences were noted. When grown to stationary phase, isolate 328 was more adherent to Hep-2 and HaCaT cells than isolate 322; in Hep-2 cells, isolate 328 was internalized better than isolate 322. Isolate 322 displayed a more mucoidal appearance, produced a clearer zone of hemolysis and in broth, grew faster and to a higher absorbance with a less turbid broth appearance compared to 328. Differences in fibronectin binding as measured by enzyme-linked assays were found between the exponential and stationary growth phases of the isolates. The most remarkable difference was that isoiate 328 completely lacked speB activity compared to isolate 322 whose speB activity peaked during late exponential growth and continued throughout the stationary phase. The data support the idea that isolate 322 are 328 are closely related and the multiple phenotypic differences might be explained by a change in some, as yet, unidentified regulatory component. xiii, 124 leaves Fri, 01 Aug 2003 00:00:00 GMT http://hdl.handle.net/10125/6851 2003-08-01T00:00:00Z Abe, Lucienne M